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Globally, an estimated 13 percent of all cancer cases in 2018 were attributable to pathogenic infections, with more than 90 percent of these cases attributable to four pathogens: human papillomavirus (HPV), hepatitis B (HBV), hepatitis C (HCV), and Helicobacter pylori (177)(178)

Additional work is needed to determine if compensatory smoking may lead to increased toxicant exposure, and if a subset of individuals choosing lower nicotine cigarettes may continue to smoke regardless of nicotine content

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adults who perceived e-cigarettes to be less harmful than cigarettes decreased from 17.6% in 2018 to 11.4% in 2020 while the perception that they are more harmful increased from 6.8% in 2018 to 28.3% in 2020 [16]

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